SFU researchers looking to fight drug-resistant superbugs
Assistant professor Amy Lee said antimicrobial resistant happens when disease-causing bacteria has ways to overcome the antibiotics use in treatment for infections.
Lee, who is part of SFU’s Department of Molecular Biology and Biochemistry, said the lab is trying to understand how bacteria develop resistance since it makes the drug ineffective.The study’s lead author Venus Lau was most interested in was Pseudomonas aeruginosa, which is “known to be naturally resistant to drugs based on their cell membranes.” It can cause infections in the blood, lungs or other parts of the body, particularly in those who are ill or recovering from surgery in hospital.
“Drugs don’t get into this bacterium easily and they tend to acquire other resistance mechanisms over time. It’s a difficult bug to treat.”an alternative approach to treating bacterial infections with antibiotics to overcome the issue of drug resistance involves antivirulence drugs.
Patrick Taylor, an SFU molecular biology and biochemistry post-doctoral fellow, said antivirulence therapeutics can mitigate disease and reduce the burden on the healthcare system by reducing the bacteria’s ability to cause damage, which provides time for the person’s immune system to clear the pathogen.
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